None listed
Conditions
Interventions
Others(This study is conducted to assess the efficacy of [MelatoZen] on human skin.) : Apply the product evenly to the face and inner left forearm twice daily, in the morning and evening. The product
Sponsors
Dermacle, Inc.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male and female individuals aged 20–55 years 2. Individuals who use screens for at least 6 hours per day and habitually use digital devices at night 3. Individuals who experience discomfort associated with sensitive skin, such as a sensation of heat, itching, discomfort, or fatigue 4. Individuals with dark circles caused by vascular or pigmentary factors 5. Individuals who usually experience facial itching due to dryness (skin hydration value of 39 or below) 6. Individuals who have fully understood the objective and have voluntarily filled out and signed a consent form after receiving sufficient explanation about the information that should be provided to the subjects by the principal investigator or their delegate 7. Healthy individuals without acute or chronic physical diseases, including skin diseases 8. Individuals who can be monitored during the study period
Exclusion criteria
Exclusion criteria: 1. Female who are pregnant, breast feeding or planning pregnancy 2. Individuals with abnormal skin findings at the test site 3. Individuals who have infectious skin diseases 4. Individuals who have allergies or hypersensitive skin 5. Individuals with significant nutritional disorders 6. Individuals with drug or alcohol addiction 7. Individuals with sagging under the eyes that may be mistaken for dark circles 8. Individuals who are sensitive to cosmetics, medications, or normal light exposure 9. Individuals who have received systemic steroids or phototherapy within 1 month of participating in the study 10. Individuals who have received skin care or procedures (scaling, Botox, fillers, laser treatments, tattoos) within 3 months of participating in the study 11. Individuals with mental illness or intellectual disabilities. 12. Individuals who have used topical steroid-containing skin preparations for more than 1 month for the treatment of skin diseases 13. Individuals who have not passed 3 months after participating in the same study 14. Other individuals who are considered unsuitable for the study by the principal investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dark circles(grade, brightness, melanin);Skin itching caused by dryness (VAS assessment, skin hydration, and transepidermal water loss);Skin melanin;Skin erythema index;Skin elasticity;Skin elasticity recovery;Skin tightness;skin fatigue;Skin texture (roughness);Skin tone;Sleep time;Sleep Questionnaire (PSQI-K);Mood Questionnaire (PHQ-9) ;Skin heat sensation assessment (VAS assessment);Skin sensitivity assessment (VAS assessment);Assessment of IL-1ß, IL-6, TNF-a, IL-33, and cortisol in stratum corneum samples collected by tape stripping | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction assessment | — |
Countries
Korea, Republic of
Contacts
Public ContactJeong YunJi
Dermacle, Inc.
Outcome results
None listed