Optimal timing of staged complete revascularization in STEMI with multivessel disease

OPtimal TIming of Fractional Flow Reserve-Guided Complete RevascularizatiON for Non-Infarct Related Artery in ST-Segment Elevation Myocardial Infarction with Multivessel Disease: The OPTION-STEMI2 Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0012324

Enrollment

1252

Registered

2026-07-23

Start date

2026-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : Patients presenting with ST-segment elevation myocardial infarction (STEMI) and multivessel disease during the enrollment period will be screened for eligibility and randomized aft

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Age =19 years 2) ST-segment elevation myocardial infarction (STEMI) - ST-segment elevation = 0.1 mV in at least two contiguous leads or - New-onset left bundle branch block (LBBB) 3) Primary PCI within 12 h after symptom development 4) At least 1 non-infarct related artery (non-IRA) with diameter = 2.5 mm and 50% stenosis by visual estimation

Exclusion criteria

Exclusion criteria: 1) Cardiogenic shock at initial presentation or after infarct-related artery (IRA) treatment 2) Thrombolysis in myocardial infarction flow at non-IRA = 2 3) Severe procedural complications during primary percutaneous coronary intervention that, in the judgement of the operator, preclude study enrollment 4) Non-IRA lesion unsuitable for percutaneous coronary intervention (PCI) treatment that, in the judgement of the operator, preclude study enrollment 5) Chronic total occlusion in a non-IRA 6) History of anaphylaxis to contrast agent 7) Pregnancy and lactation 8) Life expectancy 2.0 mmol/L.

Design outcomes

Primary

Measure	Time frame
Composite of all-cause death, nonfatal myocardial infarction, or all unplanned revascularization	—

Secondary

Measure	Time frame
Composite of all-cause death, nonfatal myocardial infarction, or all unplanned revascularization;All-cause death;Nonfatal myocardial infarction;All unplanned revascularization;Cardiac death;Non-cardiac death;Nonfatal spontaneous myocardial infarction;Nonfatal procedure-related myocardial infarction;Target-lesion revascularization;Target-vessel revascularization;Non-target vessel revascularization;Hospitalization for unstable angina;Hospitalization for heart failure;Stent thrombosis;Stroke;Major bleeding;Contrast-induced nephropathy	—

Measure

Time frame

Composite of all-cause death, nonfatal myocardial infarction, or all unplanned revascularization;All-cause death;Nonfatal myocardial infarction;All unplanned revascularization;Cardiac death;Non-cardiac death;Nonfatal spontaneous myocardial infarction;Nonfatal procedure-related myocardial infarction;Target-lesion revascularization;Target-vessel revascularization;Non-target vessel revascularization;Hospitalization for unstable angina;Hospitalization for heart failure;Stent thrombosis;Stroke;Major bleeding;Contrast-induced nephropathy

—

Countries

Korea, Republic of

Contacts

Public ContactMin Chul Kim

Chonnam National University Hospital

kmc3242@hanmail.net+82-62-220-6578

Outcome results