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Postoperative depression and incident dementia after major surgery

Newly diagnosed postoperative depression and incident dementia after major surgery: a nationwide retrospective cohort study based on National Health Insurance Service (NHIS) data

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0012255
Enrollment
400000
Registered
2026-07-08
Start date
2026-07-08
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Kangbuk Samsung Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult patients (aged =18 years) who underwent major cardiac (coronary artery bypass grafting, valvular surgery, or thoracic aortic surgery) or gastrointestinal surgery

Exclusion criteria

Exclusion criteria: - Exclude patients diagnosed with depression (F32, F33), dementia (F00, F01, F02, F03, G30, G31), mild cognitive impairment (F06.7, R41), Parkinson's disease (G20, G21), or cerebrovascular disease (I60, I61, I62, I63, I64, I65, I66, I67, I68, I69, G45, G46) within 5 years prior to surgery. - Exclude patients newly diagnosed with dementia (F00, F01, F02, F03, G30, G31) within 365 days after the surgery date. - Exclude patients who underwent another surgery during the follow-up period. - Exclude patients with missing values in covariates.

Design outcomes

Primary

MeasureTime frame
Incidence of postoperative dementia—

Secondary

MeasureTime frame
Incidence of postoperative dementia by age, sex, and surgery type ;Incidence of sustained postoperative opioid use—

Countries

Korea, Republic of

Contacts

Public ContactEun Jung Oh

Kangbuk Samsung Medical Center

angy02@naver.com+82-2-2001-2321

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Aug 10, 2026