Comparison of Pulmonary Vein Isolation Alone versus Pulmonary Vein Isolation with Posterior Wall Isolation for Pulse-Field Ablation in Persistent Atrial Fibrillation

Comparison of Pulmonary Vein Isolation Alone versus Pulmonary Vein Isolation with Posterior Wall Isolation for Pulse-Field Ablation in Persistent Atrial Fibrillation: A Prospective Randomized Controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0012254

Enrollment

482

Registered

2026-07-08

Start date

2026-07-03

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : 1. Pulmonary vein isolation (PVI) is performed using pulsed-field ablation. After the procedure, electrical cardioversion is performed, and patients successfully converted to sinus

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: -Patients aged 20 to 80 years who are candidates for catheter ablation for persistent atrial fibrillation -Patients eligible for catheter ablation according to existing clinical guidelines -Those without clinically significant structural heart disease (e.g., severe mitral regurgitation) -Those without contraindications to anticoagulation therapy

Exclusion criteria

Exclusion criteria: Exclusion Criteria: -Atrial fibrillation associated with severe congenital heart disease or structural heart disease -Patients with contraindications to general anesthesia or sedation for the procedure -History of prior cardiac surgery (e.g., Maze procedure, coronary artery bypass grafting) -History of atrial fibrillation catheter ablation within the past 12 months -Patients with severe left ventricular dysfunction (left ventricular ejection fraction grade 2, mechanical valve, prior mitral valve repair) -Patients with severe comorbid conditions -Patients with an expected survival of less than one year -Patients with drug or alcohol addiction -Pregnant or breastfeeding women -Any other conditions deemed by the investigator to make the patient unsuitable for study participation

Design outcomes

Primary

Measure	Time frame
Freedom from documented AF/AT/AFL =30 seconds at 12 months post-procedure	—

Secondary

Measure	Time frame
Procedure-related complications;total procedure time;length of hospital stay;AF burden;Patient-reported satisfaction (AFEQT);Hemolysis-related laboratory parameters	—

Countries

Korea, Republic of

Contacts

Public ContactJunbeom Park

Ewha Womans University Medical Center

newriser@naver.com+82-2-2650-5826

Outcome results