Theta Burst Stimulation for Upper Extremity Recovery in Subacute Stroke

Dual-session Continuous Theta-bust Stimulation Priming for Upper Limb Recovery in Patients with Subacute Stroke: A Pilot study

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CRIS

Registry ID

KCT0012217

Enrollment

Registered

2026-07-02

Start date

2026-07-03

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : [cTBS Intervention Protocol] -Theta-burst stimulation (TBS) consists of bursts of three magnetic pulses delivered at 50 Hz, with bursts repeated at 5 Hz

in the continuous TBS (cTBS) pattern, this stimulation is delivered continuously for 40 seconds. -Based on the interhemispheric inhibition model, cTBS is applied to the motor hot spot of the contrales

the two groups differ only in the application of active versus sham cTBS.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion Criteria ? Age 55–75 years ? First-ever stroke ? Subacute phase, within 3 months of stroke onset ? Unilateral upper-limb paresis due to stroke (2 = MMT [MRC scale] = 4) ? Pre-stroke mRS = 3

Exclusion criteria

Exclusion criteria: Exclusion Criteria ? History of any neurological disease associated with motor impairment ? Cognitive or language impairment severe enough to preclude meaningful participation in the clinical study ? Presence of any contraindication to transcranial magnetic stimulation (TMS) as defined by the international TMS safety guidelines (Rossi et al., Clin Neurophysiol, 2009) Contraindications for TMS 1. History of seizure or diagnosed epilepsy 2. Cardiac pacemaker implantation 3. Implanted neurostimulator 4. Any implanted ferromagnetic or electronic medical device in the head, excluding the oral cavity (e.g., cochlear implant, deep brain stimulation device, neurostimulator, intracranial aneurysm clip) 5. Implanted drug infusion pump 6. Elevated intracranial pressure 7. Current use of medications known to lower the seizure threshold

Design outcomes

Primary

Measure	Time frame
Change of Fugl-meyer upper limb score (FMA-UL) (?T2-T0)	—

Secondary

Measure	Time frame
Action Research Arm test (ARAT) ;Pegboard test (purdue);Hand grip strength test;Modified Barthel Index (MBI);Resting Motor threshold (RMT);Motor Evoked Potential (MEP) amplitude (120% Resting Motor Threshold, RMT)	—

Countries

Korea, Republic of

Contacts

Public ContactKyoung Tae Kim

Keimyung University Dongsan Hospital

zealot42@naver.com+82-53-258-7692

Outcome results