None listed
Conditions
Interventions
Others(Topical cream (exosome-based transdermal formulation) and bodyweight exercise) : Intervention Description
Participants were randomly assigned to one of four groups:
1. Active Cream + Exercise
Sponsors
Seoul National University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men and women aged 65 years and older
Exclusion criteria
Exclusion criteria: Participants meeting any of the following criteria were excluded: 1) Use of medications or dietary supplements that may affect muscle health within 2 weeks prior to the screening visit (e.g., protein powder, amino acid supplements, creatine supplements, Schisandra chinensis extract). 2) Participation in regular high-intensity exercise training within 3 months prior to the baseline visit. 3) History of major surgery within 6 months prior to the baseline visit. 4) Participation in another clinical trial within 1 month prior to the baseline visit or plans to participate in another clinical trial during the study period. 5) Presence of skin conditions that may interfere with topical application of the study product, including skin rash, wounds, or irritation. 6) Severe chronic diseases, including renal failure or liver disease. 7) Diagnosis of severe cerebrovascular disease (e.g., cerebral infarction, intracerebral hemorrhage), cardiovascular disease (e.g., angina, myocardial infarction, heart failure, arrhythmia), or pulmonary disease (e.g., chronic obstructive pulmonary disease) within 3 months prior to the screening visit. 8) Uncontrolled diabetes mellitus (fasting blood glucose >126 mg/dL). 9) Uncontrolled hypertension (systolic blood pressure =160 mmHg or diastolic blood pressure =100 mmHg). 10) Use of oral steroids or corticosteroids within 4 weeks prior to the screening visit. 11) Difficulty using a smartphone or computer. 12) Cognitive impairment or dementia that may interfere with study participation. 13) Any condition that, in the opinion of the investigator, would make participation in the study inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intramuscular lipid content, muscle quality index, and water content assessed by near-infrared spectroscopy (FITTO);Skeletal muscle mass and body fat mass assessed by bioelectrical impedance analysis (InBody 770) | — |
Secondary
| Measure | Time frame |
|---|---|
| Whole-body fat mass assessed by near-infrared spectroscopy (FITTO);Isokinetic knee flexion strength (peak torque and total work normalized to body weight) at 60°/s;Lower-extremity physical function assessed by Short Physical Performance Battery (SPPB) and Timed Up and Go (TUG) test;Grip strength (Takei);Isokinetic knee extension strength (peak torque and total work normalized to body weight) at 60°/s | — |
Countries
Korea, Republic of
Contacts
Public ContactYunho Sung
Seoul National University
Outcome results
None listed