Impact of a Hypoxia-Based Combined Exercise Intervention on Muscle Quality and Cognitive Function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0012134

Enrollment

Registered

2026-06-16

Start date

2026-09-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral : The intervention in this study consists of a 12-week combined exercise program performed three times per week, with each session lasting 60 min. Each exercise session includes a warm-up (

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Study 1 – Inclusion Criteria (Sarcopenia) 1) Women aged 65 years or older 2) Appendicular skeletal muscle mass (ASM) < 5.4 kg/m² 3) Handgrip strength < 18.0 kg 4) Short Physical Performance Battery (SPPB) score < 9 5) Individuals who voluntarily agree to participate and provide written informed consent 6) Individuals with no limitations for performing exercise Study 2 – Inclusion Criteria (Mild Cognitive Impairment) 1) Women aged 65 years or older 2) Mini-Mental State Examination (MMSE) score < 23 3) Individuals who voluntarily agree to participate and provide written informed consent 4) Individuals with no limitations for performing exercise

Exclusion criteria

Exclusion criteria: Applicable to both Study 1 and Study 2 Exclusion Criteria 1) Individuals with uncontrolled hypertension that is not adequately managed by medication 2) Individuals with musculoskeletal disorders or a history of orthopedic disease or injury within the past 6 months 3) Individuals diagnosed with neurological disorders, such as Parkinson’s disease 4) Individuals currently participating in other studies related to cognitive function or exercise interventions 5) Individuals deemed unsuitable for participation by the investigator

Design outcomes

Primary

Measure	Time frame
Muscle function and muscle morphology;Muscle regulation-related blood biomarkers;Cognitive function assessment (MMSE)	—

Secondary

Measure	Time frame
Body composition;Blood pressure;Physical function;Balance function;Cerebral blood flow;Hemodynamic response;Heart rate variability;Cardiovascular function;Neuroplasticity- and neuroprotection-related blood biomarkers	—

Countries

Korea, Republic of

Contacts

Public ContactSeonghyun Park

Konkuk University

pjin252@konkuk.ac.kr+82-2-450-3949

Outcome results