None listed
Conditions
Interventions
Drug : Applying topical steroid or topical lidocaine on post-inflammatory hyperpigmentation lesions of psoriasis patients for 6 months.
Topical steroid is Advantan Cream (Methylprednisolone aceponate
Sponsors
Ajou University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A. Psoriasis patients with post-inflammatory hyperpigmentation: Adults aged 19 years or older who fully understand the study and have voluntarily provided written informed consent to participate. Eligible participants must have residual skin lesions suspected to be post-inflammatory hyperpigmentation at sites of previous psoriatic lesions, must voluntarily desire to receive treatment for these lesions, and must perform a skin biopsy for differential diagnosis. B. As positive controls for immunohistochemical staining, paraffin-embedded tissue blocks will be used from patients who visited Dermatology between February 2017 and April 2023 and got diagnosed with post-inflammatory hyperpigmentation based on histopathological findings.
Exclusion criteria
Exclusion criteria: Individuals with an allergy to lidocaine, acute or chronic infections, hepatic or renal failure, diabetes mellitus, malignancy, or other autoimmune/autoinflammatory diseases. Also, minors, pregnant women, or those who meet the diagnostic criteria but lack sufficient data will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Colorimeter analysis;Distribution of dopamine, melanocytes, melanin pigmentation | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease activity (Psoriasis Area and Severity Index, Body Surface Area) | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Joon Park
Ajou University Hospital
Outcome results
None listed