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A Study of Blood Pressure Differences During Cardiac Surgery in Patients with Heritable Connective Tissue Disorders

Characteristics of radial-to-femoral arterial pressure gradients after cardiopulmonary bypass in patients with syndromic heritable connective tissue disorders: a prospective and retrospective observational study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0012030
Enrollment
179
Registered
2026-05-26
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Samsung Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult patients aged 18 years or older undergoing cardiac surgery with cardiopulmonary bypass. The prospective subcohort includes patients with heritable connective tissue disorders such as Marfan syndrome, Loeys-Dietz syndrome, and vascular Ehlers-Danlos syndrome.

Exclusion criteria

Exclusion criteria: Patients who previously underwent major aortic replacement or are scheduled to undergo aortic replacement during the index surgery, and patients with thoracoabdominal aortic dissection.

Design outcomes

Primary

MeasureTime frame
Occurrence of reverse femoral-to-radial pressure gradient immediately after cardiopulmonary bypass weaning—

Secondary

MeasureTime frame
Changes in arterial pressure differences between the radial and femoral arteries over time;Association between heritable connective tissue disorders and reverse arterial pressure gradient occurrence;Association between arterial waveform characteristics and arterial pressure differences—

Countries

Korea, Republic of

Contacts

Public ContactJoonsuk Bom

Samsung Medical Center

cnuhscv@gmail.com+82-2-3410-2471

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Jun 11, 2026