None listed
Conditions
Interventions
Drug : Participants will be randomly assigned in a 1:1 ratio to either the prophylactic norepinephrine group or the control group.
In the prophylactic norepinephrine group, continuous infusion of nor
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 19–80 years undergoing total thoracoscopic resection for atrial fibrillation
Exclusion criteria
Exclusion criteria: 1) Cases of moderate to severe heart valve disease 2) Cases of moderate to severe pulmonary hypertension (mean pulmonary arterial pressure, mPAP =25 mmHg or pulmonary vascular resistance, PVR >3 WU) 3) Moderate to severe right ventricular (tricuspid annular plane systolic excursion, TAPSE <17 mm) or left ventricular dysfunction (e.g., left ventricular ejection fraction, LVEF <30–35%) 4) Patients requiring inotropics/vasopressors before surgery 5) Contraindications/high-risk groups related to norepinephrine drugs - History of drug hypersensitivity, pheochromocytoma, thyrotoxicosis, administration of MAO (monoamine oxidase) inhibitors within 2 weeks 6) Pregnant women or women who may be pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypotension | — |
Secondary
| Measure | Time frame |
|---|---|
| Area under mean arterial pressure 160mmHg;Surgery interruption duration;Operator satisfaction (Likert scale 5-point scale) | — |
Countries
Korea, Republic of
Contacts
Public ContactJoon-suk Bom
Samsung Medical Center
Outcome results
None listed