Effects of combined treatment of nitrate and hypoxic conditions

Effects of combined treatment of nitrate and hypoxic conditions on cardiovascular health and physical ability improvement combined treatment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0012010

Enrollment

Registered

2026-05-19

Start date

2022-10-26

Completion date

Unknown

Last updated

2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral, Dietary Supplement : This study will use a crossover trial design in which all participants will complete placebo + normoxic condition, nitrate + normoxic condition, placebo + hypoxic cond

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: - Healthy adult males in their 20s without any disease - Participants eligible for the crossover trial design - Participants who voluntarily agreed to participate in this study and provided written informed consent

Exclusion criteria

Exclusion criteria: - Individuals with a history of severe cerebrovascular diseases (e.g., cerebral infarction, cerebral hemorrhage), cardiovascular diseases (e.g., myocardial infarction, angina), endocrine diseases, or psychiatric disorders - Individuals with uncontrolled hypertension (blood pressure = 160/100 mmHg) - Individuals with allergic reactions to beetroot juice ingredients - Individuals considered unsuitable for participation by the investigator

Design outcomes

Primary

Measure	Time frame
Metabolic function (minute ventilation (VE), oxygen uptake (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), oxygen pulse (O2pulse));skeletal muscle oxygenation (oxygenated hemoglobin (Oxy_Hb), deoxygenated hemoglobin (Deoxy_Hb), total hemoglobin (Total_Hb), tissue oxygen saturation (StO2));cardiovascular function (heart rate (HR), stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR), peripheral oxygen saturation (SpO2));blood pressure (systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP))	—

Measure

Time frame

Metabolic function (minute ventilation (VE), oxygen uptake (VO2), carbon dioxide production (VCO2), respiratory exchange ratio (RER), oxygen pulse (O2pulse));skeletal muscle oxygenation (oxygenated hemoglobin (Oxy_Hb), deoxygenated hemoglobin (Deoxy_Hb), total hemoglobin (Total_Hb), tissue oxygen saturation (StO2));cardiovascular function (heart rate (HR), stroke volume (SV), cardiac output (CO), total peripheral resistance (TPR), peripheral oxygen saturation (SpO2));blood pressure (systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse pressure (PP))

—

Secondary

Measure	Time frame
Vascular function (brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation (FMD))	—

Countries

Korea, Republic of

Contacts

Public ContactJae-Ho Choi

Konkuk University

zas1135@konkuk.ac.kr+82-2-0000-0000

Outcome results