PROgnosis according to target blood pressure in patients with CErebrovascular Stenosis and Small vessel disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011991

Enrollment

Registered

2026-05-15

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : This study is a randomized controlled trial comparing prognosis according to target blood pressure levels using antihypertensive medications. Participants will be randomly assigned to an intens

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults aged 19 years or older with cerebrovascular stenosis (=50% on MRA) and small vessel disease confirmed by MRI, diagnosed with hypertension, and who provide informed consent

Exclusion criteria

Exclusion criteria: Patients with insufficient data for outcome evaluation, those who have not undergone brain MRI/MRA, patients with pre-existing cognitive impairment (dementia), those with a history of neurological diseases or brain surgery affecting cognitive function, and those taking medications that may affect cognitive function will be excluded.

Design outcomes

Primary

Measure	Time frame
Change in Mini-Mental State Examination (MMSE) scores	—

Secondary

Measure	Time frame
Change in Clinical Dementia Rating Sum of Boxes (CDR-SB) score;Occurrence of Major Adverse Cerebrovascular and Cardiovascular Events (Symptomatic/Asymptomatic Stroke, Myocardial Infarction, Death);Change in the percentage of cerebrovascular stenosis;Change in brain volume (cortical thickness, cerebral volume, asymmetry, etc.);Evaluation of the accuracy of AI-based prognosis prediction technology	—

Countries

Korea, Republic of

Contacts

Public ContactAHN NA KOO

Chonnam National University Hospital

hello.anna9@gmail.com+82-62-220-4997

Outcome results