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Analgesic Effects of Nefopam versus Ketamine in Patients Undergoing Knee Arthroscopy

Analgesic Effects of Nefopam versus Ketamine in Patients Undergoing Knee Arthroscopy: A Pilot Randomized Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0011986
Enrollment
34
Registered
2026-05-14
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : No premedication is administered before surgery. Upon arrival in the operating room, standard monitoring is applied, including electrocardiography (ECG), pulse oximetry, and noninvasive blood p

Sponsors

Yeongnam University Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: i) Patients aged 20–64 years scheduled to undergo knee arthroscopic surgery (meniscectomy or synovectomy) under general anesthesia ii) American Society of Anesthesiologists (ASA) physical status I–II

Exclusion criteria

Exclusion criteria: 1. Patients with severe systemic disease (American Society of Anesthesiologists [ASA] physical status = III) 2. Patients with known allergies to the study drugs 3. Patients with uncontrolled central nervous system or psychiatric disorders 4. Patients with severe hepatic or renal dysfunction 5. Patients with angle-closure glaucoma 6. Patients with a history of drug or alcohol abuse 7. Patients receiving opioid or sedative therapy 8. Patients with hypersensitivity to anesthetic agents used in the study 9. Patients with morbid obesity (body mass index > 30 kg/m²) 10. Pregnant or breastfeeding women

Design outcomes

Primary

MeasureTime frame
pain score (numeric rating scale, NRS)

Secondary

MeasureTime frame
Pain score (numeric rating scale, NRS);Time to first rescue analgesic;Total consumption of rescue analgesics;Incidence of postoperative nausea and vomiting (PONV);Sedation score (Modified Observer’s Assessment of Alertness/Sedation, MOAA/S);Adverse effects (dizziness, drowsiness, dry mouth, headache, etc.)

Countries

Korea, Republic of

Contacts

Public Contactchoe eun kyung

Yeongnam University Medical Center

zzini0527@naver.com+82-53-620-3361

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: May 22, 2026