None listed
Conditions
Interventions
Drug : 1) The research team will explain the study to those who meet the inclusion and exclusion criteria and allow them sufficient time to consider participating. Afterward, informed consent for stud
Sponsors
Yonsei University Health System, Gangnam Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients (aged 19 years or older) undergoing cholecystectomy
Exclusion criteria
Exclusion criteria: • Patients with a history of adverse reactions such as allergies to the medication • Patients with unstable angina, congestive heart failure, or an electrocardiogram showing QRS > 200 msec or QTcF > 450 msec • Patients with moderate to severe renal impairment • Patients with moderate to severe hepatic impairment • Patients currently taking medications known to increase the PR or QRS interval • Patients currently taking strong CYP3A4 inhibitors • Patients with chronic pain requiring analgesics • Patients with cognitive impairment • Pregnant or lactating women • Cases where the informed consent form cannot be understood (e.g., illiteracy, cognitive impairment, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC (Area Under the Curve) 12h of pain score | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative opioid consumption at each time point;Pain score at each time point;Proportion of rescue-free patients up to each time point;Time to First Rescue Analgesic;PONV score at each time point;postoperative quality of recovery | — |
Countries
Korea, Republic of
Contacts
Public ContactHyunjik Song
Yonsei University Health System, Gangnam Severance Hospital
Outcome results
None listed