The effect of palonosetron on intestinal motility

The effect of palonosetron used for the prevention of postoperative nausea and vomiting on intestinal motility in patients undergoing laparoscopic colon or rectal resection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011888

Enrollment

150

Registered

2026-04-21

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : This study investigates the effect of intravenous palonosetron on the intestinal motility postoperatively. Palonosetron will be administered during surgery for preventing the development of pos

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Individuals who voluntarily provided written informed consent after receiving an explanation of the clinical trial 2) Male or female patients aged =20 years with colon or rectal cancer 3) Patients undergoing general anesthesia for laparoscopic colon or rectal resection 4) Patients classified as American Society of Anesthesiologists (ASA) physical status I–II 5) Patients scheduled to use patient-controlled analgesia (PCA) after surgery

Exclusion criteria

Exclusion criteria: 1) Patients with difficulty communicating 2) Patients with American Society of Anesthesiologists (ASA) physical status = III 3) Patients with prolonged QT interval on electrocardiography (>450 ms) 4) Patients with functional constipation (Bristol stool scale type 1 or 2) 5) Patients with irritable bowel syndrome 6) Patients with hypersensitivity to fentanyl, ketorolac, or 5-HT3 receptor antagonists 7) Patients receiving selective serotonin reuptake inhibitors (SSRIs) or serotonin–norepinephrine reuptake inhibitors (SNRIs) 8) Patients with a history of severe postoperative nausea and vomiting or severe motion sickness

Design outcomes

Primary

Measure	Time frame
The elapsed time to first flatus after surgery;The elapsed time to first defecation after surgery	—

Secondary

Measure	Time frame
Incidence of postoperative nausea and vomiting;postoperative pain and analgesic consumption	—

Countries

Korea, Republic of

Contacts

Public ContactAram Doo

Jeonbuk National University Hospital

ruiwin3518@gmail.com+82-63-250-1241

Outcome results