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A study comparing sensory nerve changes after thigh nerve block using two concentrations of ropivacaine in patients undergoing knee surgery

Association of Preoperative and Intraoperative Clinical Factors with Postoperative Outcomes in Patients Undergoing Orthopedic Knee Surgery: A Prospective Observational Cohort Study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0011876
Enrollment
110
Registered
2026-04-20
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

The Catholic University of Korea, Eunpyeong St. Mary's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Adult patients aged 19 to 74 years 2. Patients scheduled for elective unilateral knee surgery at Eunpyeong St. Mary’s Hospital 3. Patients undergoing a preoperative ultrasound-guided adductor canal block for perioperative analgesia 4. Patients receiving a single-shot adductor canal block with 20 mL of 0.25% ropivacaine or 20 mL of 0.5% ropivacaine as part of routine clinical practice 5. Patients able to undergo ultrasound elastographic assessment before the block, immediately after the block, and 20 minutes after the block, as well as cold sensation testing at 20 minutes after the block 6. Patients who provide written informed consent after receiving a full explanation of the study

Exclusion criteria

Exclusion criteria: 1. Patients who decline participation or are unable to provide written informed consent 2. Patients with known hypersensitivity or allergy to ropivacaine or other amide-type local anesthetics 3. Patients with local infection at the intended block site or clinically significant systemic infection 4. Patients with pre-existing sensory deficit, motor deficit, peripheral neuropathy, or other neurologic abnormality in the operative lower limb that may interfere with interpretation of saphenous nerve stiffness or cold sensation testing 5. Patients who are unable to understand or cooperate with the study procedures, making serial ultrasound assessment and sensory evaluation unreliable 6. Patients considered unsuitable for the planned adductor canal block by the attending anesthesiologist because of current bleeding risk, coagulopathy, or antithrombotic medication status 7. Patients in whom the block is performed with a concentration or volume different from the study protocol, or who receive additional peripheral nerve block(s) before the primary assessment at 20 minutes 8. Patients for whom reliable measurement or interpretation of the primary outcomes is judged to be difficult by the investigators

Design outcomes

Primary

MeasureTime frame
Peak pain score during movement on postoperative day 1

Secondary

MeasureTime frame
Loss of cold sensation in the target area at 20 minutes after adductor canal block;Change in saphenous nerve stiffness from baseline to immediately after adductor canal block;Peak pain score during PACU stay;Cumulative rescue analgesic consumption during PACU stay;Cumulative analgesic consumption on postoperative day 1, including IV PCA use and rescue analgesics;Use of rescue antiemetics during PACU stay;Change in saphenous nerve stiffness from baseline to 20 minutes after adductor canal block

Countries

Korea, Republic of

Contacts

Public ContactMinsuk Chae

The Catholic University of Korea, Eunpyeong St. Mary's Hospital

shscms@catholic.ac.kr+82-2-2030-4516

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: May 1, 2026