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Longitudinal comparison of oral microbiome changes after orthodontic treatment between young adults and middle-aged Koreans

**Comparative Analysis of Oral Microbiome Changes Following Orthodontic Treatment by Age Group: A Longitudinal Study of Middle-Aged and Young Adult Koreans**

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0011868
Enrollment
30
Registered
2026-04-17
Start date
2025-09-22
Completion date
Unknown
Last updated
2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Apple Tree Medical Foundation
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Scheduled for fixed orthodontic treatment using the same bracket system (Empower Clear) Possession of at least 20 natural teeth Able to provide written informed consent Able to complete 6-month follow-up Stable general health status

Exclusion criteria

Exclusion criteria: Antibiotic use within the past 1 month Uncontrolled systemic disease (diabetes with HbA1c >9%, immunosuppressed state) Currently pregnant or breastfeeding Planning pregnancy within the next 6 months Long-term use of medications causing xerostomia (e.g., antihistamines, antidepressants)

Design outcomes

Primary

MeasureTime frame
Oral microbiome ;Clinical periodontal parameters—

Secondary

MeasureTime frame
Demographic;Lifestyle survey—

Countries

Korea, Republic of

Contacts

Public ContactCho Mu-Yeol

Apple Tree Medical Foundation

whanduf@appleden.com+82-70-4601-5479

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Apr 23, 2026