Effect of proactive blood pressure control on preventing temperature drop during liver, biliary, and pancreas surgery

Effect of Preemptive Hemodynamic Management Strategy on Preventing Intraoperative Hypothermia in Major Hepatobiliary and Pancreatic Surgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0011840

Enrollment

140

Registered

2026-04-13

Start date

2026-04-20

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : 1. Key Details of the InterventionDrug Name: NorepinephrineDose: Starting at approximately 0.03 mcg/kg/min

titrated (decreased or increased) in real-time based on the investigator's clinical judgment to maintain target blood pressure.Route of Administration: Continuous intravenous (IV) infusionTiming and D

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing major hepatobiliary and pancreatic surgery under general anesthesia.Age = 20 and < 80 years.American Society of Anesthesiologists (ASA) physical status I, II, or III.Patients who voluntarily provide written informed consent to participate in this clinical study.

Exclusion criteria

Exclusion criteria: Age 37.5°C before anesthesia induction), or extreme body mass index (BMI > 35 kg/m² or < 18 kg/m²).History of hypersensitivity to vasopressors (e.g., norepinephrine, ephedrine, phenylephrine).Patient refusal.

Design outcomes

Primary

Measure	Time frame
Incidence of hypothermia (<36°C) following induction of anesthesia	—

Secondary

Measure	Time frame
Time weight area (TWA) <36°;Incidence of postoperative shivering;Thermal Comfort Score;Postinduction hypotension;Intraoperative hypotension; Mean arterial pressure;Time Weighted Area-Mean Arterial Pressure (TWA-MAP) <65mmHg;Demerol administration;Postanesthesia Care Unite (PACU) Discharge Readiness Time;Modified Aldrete Score;Postoperative delirium;Myocardial Injury after Noncardiac Surgery (MINS);Postoperative complication	—

Measure

Time frame

Time weight area (TWA) <36°;Incidence of postoperative shivering;Thermal Comfort Score;Postinduction hypotension;Intraoperative hypotension; Mean arterial pressure;Time Weighted Area-Mean Arterial Pressure (TWA-MAP) <65mmHg;Demerol administration;Postanesthesia Care Unite (PACU) Discharge Readiness Time;Modified Aldrete Score;Postoperative delirium;Myocardial Injury after Noncardiac Surgery (MINS);Postoperative complication

—

Countries

Korea, Republic of

Contacts

Public ContactJun-Young Park

Asan Medical Center

parkjy@amc.seoul.kr+82-2-3010-3868

Outcome results