Effect of remimazolam versus propofol infusion on 24-hour rescue opioid requirement after robot assisted gynecologic surgery

Effect of remimazolam infusion versus propofol TCI (Target Controlled Infusion) on 24-hour rescue opioid requirement after robot assisted gynecologic surgery: a double-blind randomized study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011839

Enrollment

140

Registered

2026-04-13

Start date

2026-04-13

Completion date

Unknown

Last updated

2026-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : [Common Measures] All participants are continuously monitored throughout surgery with electrocardiogram (ECG), noninvasive blood pressure (NIBP), pulse oximetry (SpO2), end-tidal carbon dioxide

Minto model, effect-site concentration [Ce] 2–6 ng/mL). [Remimazolam Group] Anesthesia is induced by intravenous infusion of remimazolam at a rate of 6–12 mg/kg/h until loss of consciousness (LOC) is

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1.Female patients aged 20 to 70 years 2.American Society of Anesthesiologists (ASA) physical status classification I–III 3.Scheduled to undergo gynecologic robotic surgery under general anesthesia

Exclusion criteria

Exclusion criteria: 1.Chronic opioid use or opioid tolerance 2.Known hypersensitivity to benzodiazepines or propofol 3.Severe hepatic, cardiovascular, or respiratory disease 4.Severe obstructive sleep apnea 5.Current use of psychiatric or neurological medications that may significantly affect pain perception or assessment 6.Body mass index (BMI) > 35 kg/m² 7.Pregnant women 8.Inability to provide informed consent

Design outcomes

Primary

Measure	Time frame
Cumulative rescue opioid requirement during the first 24 postoperative hours	—

Secondary

Measure	Time frame
Numeric Rating Scale (NRS) pain score;Total intraoperative remifentanil consumption;Incidence of postoperative nausea and vomiting (PONV);Modified Aldrete Score in the post-anesthesia care unit (PACU);Quality of Recovery-15 (QoR-15) score	—

Countries

Korea, Republic of

Contacts

Public ContactANN HEE YOU

Kyung Hee University

ahyou@khu.ac.kr+82-2-958-8581

Outcome results