None listed
Conditions
Interventions
None listed
Sponsors
Inje University Haeundae Paik Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults aged 30–80 years Able to provide written informed consent Phase 1 (retrospective cohort) Patients not diagnosed with MSA at initial evaluation but later diagnosed with clinically probable or clinically established MSA during follow-up Control groups: patients with Parkinson’s disease or hereditary ataxia Phase 2 (prospective cohort) Patients classified at baseline as one of the following: mono-system MSA (motor subtype) possible prodromal MSA according to MDS criteria pure autonomic failure (PAF)
Exclusion criteria
Exclusion criteria: Presence of alternative diagnoses explaining the symptoms (e.g., hereditary ataxia, drug-induced parkinsonism, structural brain lesions) Inability to comply with study procedures or follow-up Any condition deemed inappropriate by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to conversion to probable or clinically established multiple system atrophy based on MDS criteria | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in clinical features, MRI-based structural changes, and a-synuclein biomarkers between converters and non-converters, as well as predictors of conversion to multiple system atrophy, will be evaluated. | — |
Countries
Korea, Republic of
Contacts
Public ContactJUHEE KIM
Inje University Haeundae Paik Hospital
Outcome results
None listed