Empirical Anatomy-Based Ablation vs Emphasize Map-Guided Substrate Ablation in Persistent Atrial Fibrillation (COMPASS-AF)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011829

Enrollment

360

Registered

2026-04-09

Start date

2026-05-04

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : In the empirical anatomy-based ablation group, pulmonary vein isolation is performed via pulsed field ablation using a single-shot multielectrode catheter. In the Emphasize map-gui

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Adults aged 19 years or older who voluntarily provide written informed consent to participate in the study. ? Patients diagnosed with persistent atrial fibrillation who are scheduled to undergo catheter ablation for atrial fibrillation.

Exclusion criteria

Exclusion criteria: ? Prior history of catheter ablation or MAZE surgery for atrial fibrillation. ? Left atrial (LA) diameter exceeding 60 mm. ? End-stage renal disease (ESRD). ? History of prior open-heart surgery. ? Pregnancy or women of childbearing potential. ? Heart failure patients categorized as New York Heart Association (NYHA) functional class IV. ? Acute coronary syndrome (ACS) within the previous 3 months. ? Terminal illness with a life expectancy of less than 1 year. ? Any other condition deemed inappropriate for study participation by the investigator.

Design outcomes

Primary

Measure	Time frame
Any documented atrial tachyarrhythmias excluding the initial 3-month blanking period. Documented atrial tachyarrhythmias	—

Secondary

Measure	Time frame
Atrial fibrillation burden;Repeat ablation;Use of antiarrhythmic drug therapy;Atrial Fibrillation Effect on Quality-of-Life (AFEQT) score;Stroke;Cardiovascular hospitalization;Bleeding;All cause mortality;Procedure-related complication;Procedure time;Radiation time;Left atrial global strain	—

Countries

Korea, Republic of

Contacts

Public ContactJuyoun Kim

Samsung Medical Center

kzzoo921@gmail.com+82-2-3410-3419

Outcome results