None listed
Conditions
Interventions
Behavioral : This is a single-arm pilot study in patients with monoclonal gammopathy of undetermined significance and smoldering multiple myeloma, implementing a 12-week dietary intervention using a K
Sponsors
Seoul National University Bundang Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults aged 19–80 years diagnosed with MGUS or SMM Body mass index (BMI) = 25 Sufficient physical and mental ability to adhere to the KORMED diet Ability to use a smartphone and wearable device Willingness to provide informed consent for study participation
Exclusion criteria
Exclusion criteria: Presence of multiple myeloma or other malignant hematologic diseases (e.g., leukemia, lymphoma, or any other hematologic malignancy according to the WHO classification) Serious comorbidities: Heart failure: New York Heart Association (NYHA) functional class III or IV heart failure Renal failure: eGFR < 30 mL/min/1.73 m² (by CKD-EPI eGFR) Diseases requiring dietary restriction (e.g., Crohn’s disease, ulcerative colitis, malabsorption syndrome, advanced liver cirrhosis*). *Advanced liver cirrhosis defined by clinically or radiologically confirmed ascites, history of hepatic encephalopathy, history of esophageal/gastric variceal bleeding, hepatorenal syndrome, or spontaneous bacterial peritonitis. K-MEDAS score = 8 (already adherent to a Mediterranean diet) Severe limitation in walking ability (in the judgment of the treating physician, able to walk only = 1,000 steps per day, or requiring continuous use of walking aids such as a wheelchair or crutches).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Korean-style Mediterranean Diet feasibility | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI (with a target reduction of 5–7%) | — |
Countries
Korea, Republic of
Contacts
Public ContactJi Yun Lee
Seoul National University Bundang Hospital
Outcome results
None listed