Comparison of intravenous and oral dexamethasone in perioperative pain control after total knee arthroplasty

Comparison of intravenous and oral dexamethasone in perioperative pain control after total knee arthroplasty: A Prospective, Randomized Controlled, Non-inferiority Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011788

Enrollment

Registered

2026-03-30

Start date

2026-04-06

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : This study is a prospective, randomized, non-inferiority interventional trial comparing oral dexamethasone with intravenous dexamethasone in patients undergoing total knee arthroplasty. Partici

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients diagnosed with primary knee osteoarthritis who undergo total joint arthroplasty are eligible. - In cases where bilateral procedures are performed during the same hospitalization at separate time points, only the first operated knee will be included in the study.

Exclusion criteria

Exclusion criteria: A. Patients with types of arthritis other than primary osteoarthritis (e.g., rheumatoid arthritis, inflammatory arthritis, post-traumatic arthritis, neuropathic arthropathy) B. Patients currently taking neuropsychiatric medications C. Patients diagnosed with diabetes mellitus, or those with a preoperative glycated hemoglobin (HbA1c) level = 6.5% even without a prior diagnosis D. Patients receiving corticosteroids preoperatively due to underlying medical conditions E. Patients who wish to use patient-controlled analgesia (PCA) after surgery F. Patients with chronic kidney disease or a glomerular filtration rate (GFR) < 60 mL/min/1.73 m², in whom postoperative use of anti-inflammatory drugs is limited

Design outcomes

Primary

Measure	Time frame
The mean numerical rating scale(NRS) pain score during activity from the day of surgery to postoperative day 5.	—

Secondary

Measure	Time frame
Numerical rating scale(NRS) pain scores at rest and during activity from the day of surgery to postoperative day 5; Amount of rescue analgesics administered from the day of surgery to postoperative day 5;Severity of nausea and vomiting from the day of surgery to postoperative day 5;Adverse events;Patient-reported outcome measures (PROMs)	—

Countries

Korea, Republic of

Contacts

Public ContactJisu Park

Seoul Metropolitan Government Seoul National University Boramae Medical Center

pjswltn@gmail.com+82-2-870-2312

Outcome results