None listed
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adults aged 55 years or older 2.Currently enrolled or scheduled to enroll in the community-based forest therapy program (6080 Village Forest Friends) (experimental group), or community-dwelling adults of the same age range who do not participate in the program (control group) 3.Willing and able to provide saliva samples, gargle solution samples, complete the cognitive function test (MMSE-K), and answer questionnaires 4.Agreeable to the secondary use of anonymized data and residual biological specimens for future research 5.Provided written informed consent for both the study participation consent form and the human-derived materials research consent form
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics (oral or injectable) within the past 1 week 2. Participation in another clinical study within the past 1 month 3. Currently taking systemic corticosteroid medications (may interfere with salivary cortisol measurement) 4. Presence of acute oral infection 5. Diagnosed with dementia 6. Deemed ineligible for study participation by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in salivary cortisol concentration Salivary cortisol levels (nmol/L) measured by enzyme-linked immunosorbent assay (ELISA) as a physiological biomarker of stress. The primary outcome is the change in salivary cortisol concentration from baseline to post-intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in cognitive function score (MMSE-K) Cognitive function assessed using the Mini-Mental State Examination-Korean version (MMSE-K). The outcome is the change in total score from baseline to post-intervention. | — |
Countries
Korea, Republic of
Contacts
Apple Tree Medical Foundation