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Effectiveness of Transcutaneous Vagus Nerve Stimulation for Blood Pressure Regulation Based on Biomarker Assessment

Effectiveness of Transcutaneous Vagus Nerve Stimulation for Blood Pressure Regulation Based on Biomarker Assessment

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CRIS
Registry ID
KCT0011752
Enrollment
40
Registered
2026-03-20
Start date
2025-05-25
Completion date
Unknown
Last updated
2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Medical Device : All participants are randomly assigned to one of two intervention sequences. Group A: active transcutaneous auricular vagus nerve stimulation (taVNS) ? washout period of at least 2 da
frequency, 25 Hz
pulse width, 250 µs
and intensity, set at the sensory threshold level. In the sham condition, the same electrodes are attached at the same location, but no electrical stimulation is delivered. At each visit, both pre-sti

Sponsors

Hanyang University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Participants were healthy adults aged between 19 and 60 years with normal blood pressure (systolic blood pressure =130 mmHg and diastolic blood pressure =80 mmHg), and without any known psychiatric or medical conditions that could affect study participation.

Exclusion criteria

Exclusion criteria: Participants were excluded if they met any of the following criteria: 1. Hypertension (systolic blood pressure =140 mmHg or diastolic blood pressure =90 mmHg) or prehypertension (systolic blood pressure 130–139 mmHg or diastolic blood pressure 80–89 mmHg) 2. History of cardiovascular disease or use of medications affecting cardiovascular function 3. Difficulty in communication or inability to understand study procedures 4. Non-compliance with study instructions or inability to cooperate with the experimental protocol 5. Refusal to participate or withdrawal of consent during the study

Design outcomes

Primary

MeasureTime frame
Baroreflex Sensitivity (BRS)

Secondary

MeasureTime frame
Heart Rate Variability (HRV)

Countries

Korea, Republic of

Contacts

Public ContactGeonhee Lee

Hanyang University

lghee1158@hanyang.ac.kr+82-2-2220-0698

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Apr 3, 2026