Comparison of postoperative inflammatory effect of intraoperative pain control; A randomized controlled trial

Comparison of postoperative inflammatory effect of intraoperative opioid and multimodal analgesia; A randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011651

Enrollment

102

Registered

2026-02-25

Start date

2026-03-23

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Anesthetic management was maintained identically in both groups

however, the intraoperative analgesic strategy differed. In the remifentanil group, opioid analgesics were used to actively control nociception, targeting an Analgesia Nociception Index (ANI) of 50. I

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults (aged =20 years) undergoing bowel resection for colon cancer. American Society of Anesthesiologists (ASA) physical status class I–III.

Exclusion criteria

Exclusion criteria: Patients requiring creation of a rectal tube or stoma postoperatively. Patients with arrhythmia, cardiac conduction abnormalities (e.g., atrioventricular block or heart block), or those with an implanted pacemaker. Documented bradycardia with a heart rate 5%). Patients with a history of adverse reactions to the study anesthetic agents or with contraindications to these drugs (e.g., anticipated allergic reactions). Patients deemed unsuitable for participation by the investigator. Patients with obesity (BMI >40 kg·m?²; morbid obesity).

Design outcomes

Primary

Measure	Time frame
IL-6 (pro-inflammatory)	—

Secondary

Measure	Time frame
matrix metalloproteinase-9 (MMP-9);postoperative maximum pain level (NRS 0~10);postopeative analgesics consumption;the use of antiemetics for rescue ;postoperative nausea/vomiting (yes vs no);hemodynamic parameters (blood pressure, heart rate, Analgesia nociception index, Bispectral index);the amount of remifentanil, dexmedetomidine, lidocaine, rocuronicum use;the drug amount for management of blood pressure (inotropics/vasopressor, anti-hypertension);EEG: Comparison of changes in alpha power and alpha/delta phase–amplitude coupling between groups (if analgesia is adequately maintained, no significant differences in amplitude would be observed at each time point).	—

Measure

Time frame

matrix metalloproteinase-9 (MMP-9);postoperative maximum pain level (NRS 0~10);postopeative analgesics consumption;the use of antiemetics for rescue ;postoperative nausea/vomiting (yes vs no);hemodynamic parameters (blood pressure, heart rate, Analgesia nociception index, Bispectral index);the amount of remifentanil, dexmedetomidine, lidocaine, rocuronicum use;the drug amount for management of blood pressure (inotropics/vasopressor, anti-hypertension);EEG: Comparison of changes in alpha power and alpha/delta phase–amplitude coupling between groups (if analgesia is adequately maintained, no significant differences in amplitude would be observed at each time point).

—

Countries

Korea, Republic of

Contacts

Public ContactMiHye Park

Samsung Medical Center

dukiduck@gmail.com+82-2-6190-5258

Outcome results