The Relationship Between Anesthesia Type and Inflammation After Spinal Fusion Surgery

Comparison of Remimazolam-Based and Propofol-Based Total Intravenous Anesthesia on Postoperative Inflammatory Response in One-Level Lumbar Fusion Surgery: A Prospective Randomized control Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011641

Enrollment

118

Registered

2026-02-24

Start date

2026-03-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : The intervention in this study consists of the type of hypnotic agent used for general anesthesia. Eligible participants undergoing single-level lumbar fusion surgery are randomly assigned to r

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age: Adults aged 19 years or older (no upper age limit) Sex: Both male and female participants are eligible Diagnosis: Patients diagnosed with degenerative lumbar spine diseases (ICD-10 codes including M48.06, M48.07, M43.16, M47.26, M51.16, M54.16) Surgical procedure: Scheduled for single-level lumbar fusion surgery Anesthesia: Planned to undergo general anesthesia with total intravenous anesthesia (TIVA) Physical status: ASA physical status I–II Consent: Ability to provide written informed consent after receiving adequate explanation of the study

Exclusion criteria

Exclusion criteria: Patients receiving systemic immunosuppressive agents or systemic corticosteroids Patients with severe hepatic or renal dysfunction Patients with active infectious or inflammatory diseases Patients with a history of drug hypersensitivity reactions

Design outcomes

Primary

Measure	Time frame
Serum interleukin-6 (IL-6) concentration	—

Secondary

Measure	Time frame
White blood cell count (WBC);Neutrophil-to-Lymphocyte Ratio, NLR;C-reactive protein;Postoperative pain score using the Visual Analog Scale (VAS);Intraoperative opioid consumption;Total opioid consumption during the first 24 hours postoperatively (0–24 h)	—

Countries

Korea, Republic of

Contacts

Public ContactSooJung Park

Yonsei University Health System, Severance Hospital

crystal@yuhs.ac+82-2-2228-4430

Outcome results