Evaluation of Safety and Efficacy of Radiofrequency Ablation for Primary Papillary Thyroid Carcinoma without Suspected Lymph Node Metastasis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011602

Enrollment

Registered

2026-02-11

Start date

2025-11-17

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Procedure/Surgery : Radiofrequency ablation (RFA) is performed by an experienced specialist in an outpatient or inpatient setting. Under local anesthesia, a radiofrequency electrode delivers thermal e

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Inclusion criteria Adults aged 19 years or older with T1N0M0 papillary thyroid carcinoma (PTC), defined as single or multiple tumors =2 cm, and with no suspected lymph node metastasis on preoperative neck ultrasonography and/or neck CT. All participants must have a histologic or cytologic confirmation of PTC. Eligible participants are those who decline surgery or for whom surgery is difficult or unsuitable.

Exclusion criteria

Exclusion criteria: 2) Exclusion criteria Participants will be excluded if any of the following apply: Suspected or confirmed lymph node metastasis or distant metastasis on imaging or pathology. Suspected extrathyroidal extension on ultrasound, or suspected invasion of adjacent critical structures (e.g., recurrent laryngeal nerve, trachea, esophagus). Prior history of thyroid surgery or radiofrequency ablation of the thyroid. Pregnant or breastfeeding women. Bleeding disorder, or inability to discontinue anticoagulant therapy. Inability to understand the study explanation or provide informed consent. Any other condition deemed by the investigator to make the participant unsuitable for trial participation.

Design outcomes

Primary

Measure	Time frame
Tumor volume reduction rate (Volume Reduction Rate, VRR)	—

Secondary

Measure	Time frame
Procedure-related complication rate: Adverse events occurring immediately after the procedure or during follow-up will be recorded (e.g., voice changes, bleeding, burns, pain);Permanent nerve injury or functional impairment will also be assessed, including recurrent laryngeal nerve injury, hypoparathyroidism, and hypothyroidism.	—

Countries

Korea, Republic of

Contacts

Public ContactYOUNG JUN CHAI

Seoul Metropolitan Government Seoul National University Boramae Medical Center

kevinjoon@naver.com+82-2-870-3294

Outcome results