None listed
Conditions
Interventions
Drug : This study aims to compare the effect of early Wegovy (semaglutide) administration on post-fasting gastric emptying in the same patients by measuring residual gastric volume using ultrasound. T
Sponsors
Samsung Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) physical status classification I–II. (2) Overweight or obesity according to the Korean Society for the Study of Obesity criteria: body mass index (BMI) = 23 kg/m². (3) Age = 20 years. (4) Patients with uterine diseases associated with overweight, such as endometriosis, premalignant endometrial lesions, or adenomyosis. (5) Patients in whom surgical treatment by the Department of Obstetrics and Gynecology has been decided for the conditions described in (4). (6) Patients undergoing laparoscopic surgery involving the uterus and/or extrauterine adnexal structures. (7) Patients using highly effective contraception: the contraceptive methods specified in Exclusion Criteria 2(3)? must be used.
Exclusion criteria
Exclusion criteria: (1) Patients with unstable vital signs. (2) Pregnant or breastfeeding women. (3) Women with childbearing potential: premenopausal women must be instructed to adhere to contraception during the surgical preparation period (2 months prior to surgery). Acceptable contraceptive methods include oral contraceptives, implantable contraceptive devices, or male barrier methods. ? Definition of women of childbearing potential: women with menstrual cycles including ovulation. ? Contraception period: contraception must be maintained for 8 weeks (2 months) from the time surgery is decided until surgery is performed, as part of routine preparation for general anesthesia. Contraceptive methods listed in ? will be explained during outpatient visits. ? Contraceptive methods: in addition to natural cycle methods, oral contraceptives, implantable contraceptive devices, and secondary barrier methods (male contraceptive devices) are recommended. ? Pregnancy status will be confirmed by urine hCG testing as part of routine preoperative evaluation. Surgery will be cancelled if pregnancy is confirmed. ? If future pregnancy is planned, contraception must be maintained for 8 weeks after discontinuation of Wegovy. (4) Patients at high anesthetic risk (see item (5)) for whom laparoscopic surgery is not appropriate. (5) Patients at high risk of pulmonary aspiration, including those with diabetes mellitus, gastro-oesophageal reflux, renal failure, oesophageal strictures, achalasia, enteropathies, or a history of gastrointestinal tumors. (6) Patients taking medications that may affect gastrointestinal motility (7) Patients with contraindications to or allergy to the investigational drug Wegovy (semaglutide): (8) Emergency surgery. (9) Patients who do not consent to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastric volume measured by ultrasound immediately before surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastric volume measured by ultrasound 6 hours after the last meal.;Gastric volume measured by ultrasound 8 hours after the last meal.;Gastric volume measured by ultrasound 6 hours before surgery;Incidence of nausea and vomiting during the first hour after surgery.;Incidence of nausea and vomiting during the first 24 hours after surgery.;Dose of antiemetics administered during the first hour after surgery for the treatment of postoperative nausea and vomiting.;Dose of antiemetics administered during the first 24 hours after surgery for the treatment of postoperative nausea and vomiting. | — |
Countries
Korea, Republic of
Contacts
Public ContactYu Jeong Bang
Samsung Medical Center
Outcome results
None listed