None listed
Conditions
Interventions
Dietary Supplement : Participants in the test group will be assigned to receive the test product containing Meriva® (curcumin extract), while participants in the control group will be assigned to rece
Sponsors
Ildong Bioscience
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult men and women aged 45 to 79 years 2. Radiographic evidence of Kellgren–Lawrence Grade I or II in one or both knee joints 3. Knee pain score = 30 mm on a 100-mm Visual Analog Scale (VAS) 4. Provided written informed consent after receiving sufficient explanation of the study
Exclusion criteria
Exclusion criteria: 1. Suspected rheumatoid arthritis or positive rheumatoid factor 2. Participation in another clinical trial within the past 12 weeks 3. History of knee surgery or musculoskeletal disorders affecting the knee, spine, or lower limbs 4. Autoimmune, inflammatory, infectious joint diseases, or gout 5. Recent use of joint-related functional foods or medications that may affect study outcomes 6. Habitual use of central nervous system drugs or narcotic analgesics 7. History of hypersensitivity to the test product or its ingredients 8. Clinically significant hepatic, renal, cardiovascular disease, or malignancy 9. Pregnant or breastfeeding women, or women of childbearing potential not using appropriate contraception 10. Abnormal laboratory findings or uncontrolled hypertension 11. Any condition deemed unsuitable for participation by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC questionnaire total score | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS(Visual Analogue Scale, 100 mm) pain score;WOMAC subscale score (pain, stiffness, physical function);Inflammatory and joint-related biomarkers (CRP, COX-2, COMP, CTX-II);Walking time (20-m walk test);WOMAC total score and subscale score | — |
Countries
Korea, Republic of
Contacts
Public ContactJunyoung Park
Yonsei University Yongin Severance Hospital
Outcome results
None listed