None listed
Conditions
Interventions
None listed
Sponsors
Apple Tree Medical Foundation
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Periodontitis Group: Moderate to severe periodontitis. Maximum Clinical Attachment Loss (CAL) > 5mm. Radiographic evidence of bone loss in 5 or more teeth. Healthy Group: Clinically healthy periodontal tissue. Probing Pocket Depth (PPD) = 3mm. No Clinical Attachment Loss (CAL).
Exclusion criteria
Exclusion criteria: Individuals who have taken anti-inflammatory or immunosuppressive medications within the last 3 months. Individuals who received antibiotic treatment within the last 6 months or periodontal treatment (scaling and root planing) within the last 3 months. Patients with uncontrolled systemic diseases. Pregnant women or women planning to become pregnant. Patients with cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, or neuropsychiatric disorders. Patients with thyroid diseases (hyperthyroidism or hypothyroidism). Individuals with a history of oral malignant tumors. Patients with other oral inflammatory diseases, including oral cancer, ulcers, herpes simplex, herpes zoster, or fungal/bacterial infections. Individuals with a history of drug or alcohol abuse within the last year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of 6 oral pathogens in oral samples using quantitative analysis;Microbial composition in oral samples using next generation sequencing | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantification of five inflammatory protein biomarkers in samples using Enzyme-Linked Immunosorbent Assay;Probing depth;Bleeding on probing;Gingival recession;Gingival index;Clinical attachment loss | — |
Countries
Korea, Republic of
Contacts
Public ContactMu-Yeol Cho
Apple Tree Medical Foundation
Outcome results
None listed