The effect of perioperative nefopam administration on postoperative depressive mood

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CRIS

Registry ID

KCT0011490

Enrollment

114

Registered

2026-01-19

Start date

2026-01-21

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : The study investigator will explain the study to eligible participants who meet the inclusion criteria, allowing them sufficient time to consider their participation. Afterward, the investigato

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients (aged 19 years and older) scheduled for lumbar fusion surgery, classified as ASA-PS (American Society of Anesthesiologists Physical Status) I-III.

Exclusion criteria

Exclusion criteria: Patients with a history of allergic reactions or adverse effects to the study drug (Nefopam) Patients taking psychiatric or neurological medications other than antidepressants Patients with seizure disorders Patients at risk of urinary retention due to urethral or prostate issues Patients with closed-angle glaucoma (risk of increased intraocular pressure) Patients at high risk of respiratory depression, such as those with severe asthma or chronic obstructive pulmonary disease (COPD) Patients with severe liver or kidney dysfunction (eGFR <30 mL/min) Patients with severe cardiovascular conditions (e.g., myocardial infarction, severe hypotension, severe arrhythmias) Pregnant or breastfeeding women Patients who experience severe complications after surgery, such as life-threatening bleeding, nerve damage, or the need for reoperation Patients unable to understand the consent form or answer the research questionnaires due to cognitive impairment Patients unable to read the consent form (e.g., illiterate or foreign nationals)

Design outcomes

Primary

Measure	Time frame
postoperative depressive mood	—

Secondary

Measure	Time frame
postoperative depressive mood;postoperative depressive mood;postoperative anxiety mood;postoperative quality of recovery;The dose of remifentanil administered during anesthesia.;pain score;Postoperative nausea/vomiting score and the amount of analgesics and antiemetics required.;postoperative complications;post-anesthesia recovery unit stay time and hospital stay duration	—

Countries

Korea, Republic of

Contacts

Public ContactHyunjik Song

Yonsei University Health System, Gangnam Severance Hospital

anehjsong@gmail.com+82-2-2019-6692

Outcome results