None listed
Conditions
Interventions
Drug : 1) The researcher explains the study to candidates meeting the inclusion criteria before surgery, allows them sufficient time to consider participation, and then revisits to obtain informed con
Sponsors
Yonsei University Health System, Gangnam Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult patients (aged =19 years) with breast cancer undergoing mastectomy, classified as ASA-PS (American Society of Anesthesiologists Physical Status) I-IV.
Exclusion criteria
Exclusion criteria: History of allergy or severe adverse reaction to the study drug (N2O). Currently receiving psychiatric or neurological medication other than antidepressants. Pregnant or having the potential for pregnancy during the study period. Occurrence of life-threatening postoperative complications (e.g., severe hemorrhage, nerve damage) or complications requiring reoperation. Cognitive impairment preventing comprehension of study information or completion of questionnaires. Inability to read the informed consent form (e.g., illiteracy, non-Korean speaking). Voluntary withdrawal from study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative depressive mood | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative depressive mood;postoperative anxiety mood;pain score;Postoperative nausea/vomiting score and the amount of analgesics and antiemetics required;postoperative complications;post-anesthesia recovery unit stay time and hospital stay duration | — |
Countries
Korea, Republic of
Contacts
Public ContactHyunjik Song
Yonsei University Health System, Gangnam Severance Hospital
Outcome results
None listed