Fentanyl Dose Required to Achieve Hemodynamic Stability During Tracheal Intubation Following Remimazolam Bolus Induction: A Dixon’s Up-and-Down Dose–Response Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011429

Enrollment

Registered

2026-01-09

Start date

2026-01-11

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : The study dose of fentanyl (starting at 1 µg/kg) is administered as an intravenous bolus over 30–60 seconds. Remimazolam is then given for anesthetic induction, and after confirming loss of res

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Adult patients aged 19–64 years scheduled for elective noncardiac surgery requiring general anesthesia with tracheal intubation. 2.Patients with an American Society of Anesthesiologists (ASA) physical status classification of I or II.

Exclusion criteria

Exclusion criteria: Patients with an anticipated difficult tracheal intubation Patients with psychiatric disorders Patients with cognitive impairment Patients with heart failure or a history of myocardial infarction within the past 6 months Patients with severe arrhythmias Patients with severe pulmonary disease Patients with a history of hypersensitivity to remimazolam or fentanyl Pregnant or breastfeeding women Any other condition deemed inappropriate for study participation by the investigator

Design outcomes

Primary

Measure	Time frame
hemodynamic stability during intubation	—

Secondary

Measure	Time frame
hypotension;bradycardia;hypertension;tachycardia; frequency of vasopressor ;frequency of or antihypertensive agents	—

Countries

Korea, Republic of

Contacts

Public ContactSungae Cho

Samsung Changwon Medical Center

sachosa@naver.com+82-55-233-6045

Outcome results