None listed
Conditions
Interventions
None listed
Sponsors
Yonsei University, Wonju Severance Christian Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ? Subjects who have received consent ? Adults aged 19 years or older ? Subjects admitted to the emergency room ? Patients diagnosed with acute CO poisoning ? Subjects hospitalized ? Patients with a COGAS score of 1 or higher
Exclusion criteria
Exclusion criteria: ? Patients who did not consent to the study ? Patients under 19 years of age ? Pregnant women ? Inmates and institutionalized persons ? Employees of research institutions, researchers, sponsors, etc. ? Patients with persistent neurological complications (PNS) due to severe CO intoxication ? Cardiac arrest prior to hyperbaric oxygen therapy ? History of neurological disease ? Patients with a critical medical history (e.g., terminal cancer) ? Patients transferred without hospitalization ? Patients who cannot undergo MRI due to implanted pacemakers, cochlear implants, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of Delayed Neurologic Sequelae (DNS);Neurologic status assessments: Geriatric Depression Scale (GDS), Mini-Mental Status Exam (MMSE, Korean version), Korean version of Modified Barthel Index (KMBI);Brain MRI findings: presence of high signal intensity lesions | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in serum biomarkers: Serum Myelin Basic Protein (MBP), Serum Neuron-Specific Enolase (NSE), Serum S-100 protein | — |
Countries
Korea, Republic of
Contacts
Public ContactHee Young Lee
Yonsei University Wonju College of Medicine
Outcome results
None listed