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A Study on Ischemic Penumbra Recovery and Prognosis Changes in Acute Ischemic Stroke Patients Receiving Hyperbaric Oxygen Therapy

Effect of Hyperbaric Oxygen Therapy on Ischemic Penumbra Recovery and Neurological Outcomes in Acute Ischemic Stroke: A Prospective Non-Randomized Comparative Clinical Study with Retrospective Control

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0011080
Enrollment
50
Registered
2025-10-30
Start date
2025-10-30
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Yonsei University, Wonju Severance Christian Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adults (aged 19 or older)

Exclusion criteria

Exclusion criteria: - Patients who are not cooperative or unable to communicate during treatment or procedures - Patients who require active intervention (vasopressors, intubation, mechanical ventilation, oxygen administration) to control vital signs - Patients who received thrombolytic therapy or intra-arterial thrombectomy - Patients who experienced seizures during cerebral infarction - Patients with a history of stroke - Pregnant women - NIHSS score > 22 - Patients with uncontrolled underlying diseases that may affect treatment (chronic renal failure, chronic liver disease (cirrhosis, hepatitis), cancer (during chemotherapy or radiation therapy), peripheral vascular occlusion (Buerger's disease), cardiovascular disease - Contraindications to hyperbaric oxygen therapy: severe chronic obstructive pulmonary disease, untreated pneumothorax, unidentified medical device attachment, epilepsy, taking certain medications (e.g., chemotherapy drugs such as doxorubicin or bleomycin), uncontrolled fever, cold or sinus infection, claustrophobia, intestinal obstruction, sickle cell disease, and other conditions identified by the investigators Evidence of cardiac arrhythmia that warrants emergency intervention

Design outcomes

Primary

MeasureTime frame
NHISS (National Institutes of Health Stroke Scale) score 0 or improvement of 4 or more from baseline)

Secondary

MeasureTime frame
Barthel Index (BI) score;Modified Rankin Scale (mRS) score;Glasgow Outcome Scale (GOS);MRI Brain + Diffusion

Countries

Korea, Republic of

Contacts

Public ContactHee Young Lee

Yonsei University Wonju College of Medicine

hylee3971@yonsei.ac.kr+82-33-741-0952

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026