None listed
Conditions
Interventions
Drug : Pre-Procedure Medication: All patients will receive a loading dose of 300 mg of aspirin and 180 mg of ticagrelor prior to undergoing percutaneous coronary intervention (PCI).
Anticoagulation:
Sponsors
Gyeongsang National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subject must be =18 years 2) Patients with a diagnosis of AMI by symptom, cardiac marker and electrocardiographic change of ST-elevation myocardial infarction or Non ST elevation myocardial infarction. 3) Thrombolysis in Myocardial Infarction flow 0, 1, or 2 before the procedure; 4) Achievement of Thrombolysis In Myocardial Infarction 3 flow after balloon angioplasty or thrombus aspiration 5) Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving invasive physiologic or imaging evaluation and he/she or his/her legally authorized representative provides written informed consent to any study related procedure.
Exclusion criteria
Exclusion criteria: 1) Cardiogenic shock (systolic blood pressure 90mmHg) or cardiac arrest 2) Rescue percutaneous coronary intervention after fibrinolysis 3) Acute occlusion of left main coronary artery 4) Major coronary dissection (type D–F) after procedures achieving Thrombolysis In Myocardial Infarction 3 flow 5) ST elevation myocardial infarction caused by stent thrombosis, 6) Non-cardiac co-morbid conditions are present with life expectancy <2 year (per site investigator’s medical judgment). 7) Inability to undergo invasive coronary physiologic assessment 8) Inability to undergo anatomical assessment (Optical Coherence Tomography, OCT) 9) Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of changes in coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) in non-infarct related artery (non-IRA) between the two groups | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of changes in thin-cap fibroatheroma (TCFA) and plaque in non-infarct related artery (non-IRA) between the two groups;Comparison of changes in thromboelastography (TEG) and fibrinogen between the two groups;Comparison of changes in high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and D-dimer between the two groups | — |
Countries
Korea, Republic of
Contacts
Public ContactYunjeong Song
Gyeongsang National University Hospital
Outcome results
None listed