How Exercise Improves Muscle Health and Body Composition in Older Adults with Sarcopenia and Sarcopenic Obesity

Effects of Exercise Intervention on Sarcopenia Biomarkers and Body Composition in Elderly Men and Women with Sarcopenia and Sarcopenic Obesity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0011005

Enrollment

200

Registered

2025-09-10

Start date

2022-02-03

Completion date

Unknown

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others(exercise intervention) : 1. Participant Classification Elderly individuals will be divided into those with sarcopenia and those with sarcopenic obesity. Each group will be further stratified by

Weeks 9–16: 60–69% 1RM) Exercise Structure: Warm-up (5–10 min) ? Main exercise (30–40 min) ? Cool-down (5–10 min) 3. Measurements and Assessments Pre- and Post-tests: Body composition (DEXA) Sarcope

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Measurement of Body Composition, Sarcopenia, and Sarcopenic Obesity Body composition will be measured using dual-energy X-ray absorptiometry (DEXA; Lunar Prodigy, GE Medical Systems, Waukesha, WI, USA). Participants will be instructed to abstain from alcohol, diuretics, and caffeine for 48 hours prior to measurement, avoid vigorous physical activity and exercise within 12 hours, and refrain from food and beverage intake for at least 4 hours before the test to minimize measurement errors. %fat will be calculated as the ratio of fat mass to body weight. Fat-free mass (FFM) will be obtained by summing the muscle mass of the right and left arms, legs, and trunk. Appendicular skeletal muscle mass (ASM) will be calculated as the sum of the muscle mass of both arms and legs. ? Criteria for Obesity and Sarcopenia Obesity will be defined according to Korean standards proposed by Lee (1992), with %fat =30%, rather than the Western criterion of 38% suggested by Baumgartner et al. (2004) and Aubertin-Leheudre et al. (2006). Sarcopenia will be diagnosed according to the criteria of the Asian Working Group for Sarcopenia in Older People (AWGSOP; Chen et al., 2020): Muscle strength: Handgrip strength <28 kg for men and <18 kg for women. Physical performance: Short Physical Performance Battery (SPPB) score <9. If these functional measures are inadequate, body composition will be assessed using DEXA. Sarcopenia will be further defined using the ASM/m² index (Baumgartner et al., 1998; Newman et al., 2003; Rolland et al., 2009; Chen et al., 2020), with cutoff values of <7.0 kg/m² for men and <5.4 kg/m² for women. Sarcopenic obesity (SO) will be defined when both the criteria for obesity and sarcopenia are satisfied.

Exclusion criteria

Exclusion criteria: The exclusion criteria for participant selection in this study are as follows: ? Individuals deemed unable to perform physical activity or exercise based on a physician’s diagnosis. ? Individuals who have participated in an exercise program at least three times per week for more than one month prior to the study. ? Individuals who do not meet the diagnostic criteria for sarcopenia (handgrip strength: <30 kg for men, <20 kg for women; physical performance: SPPB score <8) or obesity (waist circumference: =90 cm for men, =85 cm for women).

Design outcomes

Primary

Measure	Time frame
Body Composition ;Sarcopenia-related Biomarkers	—

Secondary

Measure	Time frame
Physical Function Muscle strength: Handgrip strength (cut-off: <28 kg for men, <18 kg for women) Physical performance: Short Physical Performance Battery (SPPB) score	—

Countries

Korea, Republic of

Contacts

Public ContactSung-Wook Chun

Pusan National University

onlylove8383@pusan.ac.kr+82-2-510-1845

Outcome results