None listed
Conditions
Interventions
None listed
Sponsors
Seoul National University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Radiotherapy Group: - Diagnosed with a primary brain tumor at the age of 3–18 years at the time of diagnosis - Undergoing radiotherapy for curative or adjuvant purposes for a brain tumor - Receiving treatment with a radiotherapy plan established through CT simulation to calculate radiation doses for specific brain regions - No history of prior radiotherapy - Capable of understanding and completing neurocognitive and physical function assessments - Sufficient physical activity level (Lansky score = 50) - Consent provided by the patient and their guardian for long-term follow-up and assessments Surgery-only Group: - Diagnosed with a primary brain tumor at the age of 3–18 years at the time of diagnosis - Underwent surgery for a brain tumor with curative intent - No prior history of radiotherapy and no planned radiotherapy at the time of study participation - Capable of understanding and completing neurocognitive and physical function assessments - Sufficient physical activity level (Lansky score = 50) - Consent provided by the patient and their guardian for long-term follow-up and assessments
Exclusion criteria
Exclusion criteria: - History of surgery or radiotherapy for other conditions involving the brain - Undergoing 2D radiotherapy or palliative radiotherapy - Uncontrolled seizures or altered consciousness posing a risk of falls or injury during assessments - Inability to undergo contrast-enhanced MRI for follow-up purposes - Tumor types unsuitable for long-term follow-up (e.g., inoperable brainstem glioma, high-grade glioma without curative resection, AT/RT)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurocognitive Function Assessments;Physical Function Assessments | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Outcome (e.g., survival status, recurrence);Behavioral and Emotional Assessments;Family Environment Assessments;Saliva-based genetic analysis data (Radiotherapy Group only);CT, MRI, and radiotherapy planning data related to radiotherapy | — |
Countries
Korea, Republic of
Contacts
Public ContactJoo Ho Lee
Seoul National University Hospital
Outcome results
None listed