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Comparison of laparoscopy and open living donor hepatectomy in the tolerance of liver ischemia-reperfusion injury induced by intermittent hepatic inflow occlusion

Comparison of laparoscopy and open living donor hepatectomy in the tolerance of liver ischemia-reperfusion injury induced by intermittent hepatic inflow occlusion

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0010864
Enrollment
1000
Registered
2025-08-08
Start date
2025-03-31
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Samsung Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Among living liver donors from January 2010 to March 2024, donors who underwent laparoscopic right hemi-hepatectomy between 2018 and 2024 and donors who underwent open right hemi-hepatectomy between 2010 and 2015

Exclusion criteria

Exclusion criteria: Donors underwent the surgery between the 2016 to 2017 (transition periods) Donors with incomplete data on intermittent hepatic inflow occlusion (IHIO) time Donors who underwent liver resection other than right hemi-hepatectomy Donors who initially underwent laparoscopy but required conversion to open surgery

Design outcomes

Primary

MeasureTime frame
tolerance to hepatic IHIO-induced IR injury defined by the increase in alanine transaminase (ALT) and aspartate transaminase (AST) per minute of IHIO.—

Secondary

MeasureTime frame
prolonged hospital stay (>10 days);Overall complication;Wound complication;Major complication (Clavien-Dindo classification gr>2);Biliary complication (Clavien dindo classification gr>2)—

Countries

Korea, Republic of

Contacts

Public ContactJeayoun Kim

Samsung Medical Center

kimjy0705@naver.com+82-2-3410-0362

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026