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A study predicting suicide risk in individuals with depression using brain imaging, immune markers, genetic data, and lifestyle patterns

Development of a Brain Imaging–Epigenetic–Inflammatory–Digital Phenotyping Biomarker-Based Model for Predicting Suicide Risk in Major Depressive Disorder

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0010721
Enrollment
225
Registered
2025-07-07
Start date
2025-08-19
Completion date
Unknown
Last updated
2026-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Korea University Anam Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Adults aged 19 to 55 years 2. Diagnosed with Major Depressive Disorder (MDD) according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria, confirmed through a structured diagnostic interview (Mini-International Neuropsychiatric Interview, MINI) 3. Currently experiencing a moderate or greater depressive episode (Hamilton Depression Rating Scale-17 = 17 and Clinical Global Impression – Severity = 4) 4. Voluntarily agreed to participate in the study and provided written informed consent

Exclusion criteria

Exclusion criteria: - Psychiatric Criteria 1. History or current diagnosis of schizophrenia spectrum disorder, bipolar disorder, substance use disorder (excluding nicotine), neurocognitive disorder, organic mental disorder, or neurodevelopmental disorder 2. History of major depressive episodes with psychotic features 3. Clinically significant personality disorder 4. Full-scale IQ of 80 or below - Medical/Neurological Criteria 1. Neurological conditions affecting brain function (e.g., head trauma, epilepsy, multiple sclerosis, brain tumor, cerebrovascular disease) 2. Recent history of myocardial infarction, heart failure, arrhythmia, or cardiac conduction disorders 3. Presence of metal implants or devices contraindicated for MRI 4. Claustrophobia 5. Current inflammatory disease 6. Pregnant or breastfeeding women

Design outcomes

Primary

MeasureTime frame
Occurrence of suicidal ideation and behavior, based on the Columbia-Suicide Severity Rating Scale (C-SSRS)—

Secondary

MeasureTime frame
Severity of suicidal ideation (SSI; Beck Scale for Suicidal Ideation);intent of suicidal behavior (SIS; Beck’s Suicidal Intent Scale);lethality of suicidal behavior (RRRS; Risk-Rescue Rating Scale)—

Countries

Korea, Republic of

Contacts

Public ContactMinjee Jung

Korea University

minjeejung.g@gmail.com+82-2-920-5815

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026