Effects of regular resistance exercise and supplementation of essential amino acid on inflammatory, myokine, hepatokine, Brain neuroplastic factors and cognitive function in the elderly

Effects of regular exercise program and supplementation of essential amino acid on inflammatory, myokine, hepatokine, Brain neuroplastic factors and cognitive function in the elderly

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010682

Enrollment

180

Registered

2025-06-25

Start date

2024-11-19

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral, Dietary Supplement : Intervention 1. Resistance Exercise Group: Participants will perform resistance exercise three times per week for 12 weeks. Each session will last approximately 60 min

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: (1) Individuals aged 65 years or older who were able to participate in regular resistance exercise; (2) Individuals who voluntarily agreed to participate in the study; (3) A total of 180 older adults were recruited based on their insulin resistance status, as determined by HOMA-IR values: 90 individuals with insulin resistance (HOMA-IR > 2.5) and 90 individuals without insulin resistance (HOMA-IR = 2.5).

Exclusion criteria

Exclusion criteria: (1) Individuals diagnosed with a musculoskeletal disorder in the past 6 months that prevents them from participating in walking or exercise programs; (2) Individuals with severe cardiovascular disease that precludes participation in resistance exercise programs; (3) Individuals unable to perform daily activities independently due to depression, anxiety, or insomnia; (4) Individuals currently taking any medication to lower blood glucose levels; (5) Individuals who are currently on a diet or planning to start a diet, or those already participating in two or more structured exercise sessions per week; (6) Individuals deemed unsuitable for participation in this clinical trial due to other medical conditions that may affect the outcomes, as determined by the attending physician or research staff. However, individuals taking antihypertensive or lipid-lowering medications will be allowed to participate if their medication regimen remains stable throughout the study period.

Design outcomes

Primary

Measure	Time frame
Body compositon(Height, Muscle mass, Fat mass, Fat percent);Myokine;Hepatokine;Adipokine;Insulin;neuroplasticity	—

Secondary

Measure	Time frame
physical fitness	—

Countries

Korea, Republic of

Contacts

Public ContactDeokhwa Jeong

Kangwon National University

93deokgoo@kangwon.ac.kr+82-33-250-6780

Outcome results