None listed
Conditions
Interventions
None listed
Sponsors
The Catholic University of Korea, Incheon St. Mary's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults aged 18 to 74 years Patients with chronic pain persisting for more than 6 months Candidates eligible for DBS due to inadequate response to conservative treatments Participants who provide written informed consent after receiving sufficient explanation Individuals who can undergo MRI and clinical assessments before and after DBS For the control group: Healthy adults with no history of chronic pain or neurological/psychiatric disorders
Exclusion criteria
Exclusion criteria: Individuals who cannot understand the study or provide informed consent Contraindications to MRI (e.g., metallic implants, pacemakers) Severe psychiatric illness or cognitive impairment (e.g., dementia) History of stroke, traumatic brain injury, or major neurological conditions within the past 6 months Individuals younger than 18 or older than 74 years Inability to comply with follow-up assessments up to 6 months after DBS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain assessment scores: Visual Analog Scale (VAS), Numerical Rating Scale (NRS), and Douleur Neuropathique 4 Questions (DN4) | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in structural and functional brain connectivity assessed by Diffusion Tensor Imaging (DTI) and resting-state functional MRI (rs-fMRI) | — |
Countries
Korea, Republic of
Contacts
Public ContactIL JANG
The Catholic University of Korea, Incheon St. Mary's Hospital
Outcome results
None listed