Effects of Acute Exposure to Various Environmental Conditions on Immune Response and Exercise Performance

Effect of Exercise in Heat, Cold, and Hypobaric Hypoxic Environments on Energy Metabolism, Cardiac Function, Skeletal Muscle Oxygenation, Inflammatory Cytokines, Heat Shock Protein, and Exercise Performance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010477

Enrollment

150

Registered

2025-05-20

Start date

2024-10-11

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Others(Exercise in various environmental conditions (Heat, Cold, Hypobaric hypoxia)) : This experimental study was conducted using a randomized crossover design to compare acute exercise responses und

in Study 2 (cold condition), at 20°C, 10°C, and 0°C

with humidity maintained at 50 ± 5% for both. In Study 3 (hypobaric hypoxia condition), exercise was performed in a hypobaric chamber (NCTC-1, Nara Control, Seoul, Korea) under simulated altitudes of

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Participants in this study were healthy adult males aged between 20 and 29 years who had not been exposed to high-altitude environments within the past six months and had no history of cardiovascular, respiratory, metabolic, or immune-related diseases. Only individuals who received a full explanation of the study’s purpose and procedures, understood the information provided, and voluntarily agreed to participate were included.

Exclusion criteria

Exclusion criteria: Individuals were excluded if they had been diagnosed with or were receiving treatment for cardiovascular, respiratory, metabolic, or immune-related diseases; had musculoskeletal disorders that could limit exercise performance; had a history of altitude sickness or exhibited sensitivity to high-altitude environments; reported discomfort or intolerance when exercising in hot, cold, or hypobaric hypoxic environments; or were judged by the investigators to have any condition that could compromise the safety of the intervention or the accuracy of the measurements.

Design outcomes

Primary

Measure	Time frame
Levels of inflammatory cytokines (IL-6, IL-1ß, TNF-a) and heat shock protein 70 (HSP-70)	—

Secondary

Measure	Time frame
Respiratory gas exchange variables (VE, VO2, VCO2, RER), cardiac function indicators (HR, SV, CO), muscle oxygenation variables (StO2, O2Hb, HHb, tHb), exercise time and maximal oxygen uptake (VO2max)	—

Countries

Korea, Republic of

Contacts

Public ContactEunjoo Lee

Konkuk University

eunjooo@konkuk.ac.kr+82-2-450-3949

Outcome results