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The effect of two intraoperative nociception monitoring methods on postoperative hyperalgesia and pain in patients undergoing gynecological laparoscopic surgery

Effects of 2 intraoperative nociception monitoring system (based on Pupil Measurement and Analgesia Nociception Index) on postoperative pain and opioid induced hyperalgesia in patients undergoing laparoscopic gynecologic surgery

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CRIS
Registry ID
KCT0010453
Enrollment
130
Registered
2025-04-30
Start date
2025-02-10
Completion date
Unknown
Last updated
2025-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Hanyang University Seoul Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Patients aged 20-55 years undergoing gynecological surgery under general anesthesia American Society of Anesthesiologist (ASA) physical status classification system I to II grades

Exclusion criteria

Exclusion criteria: - If the patient do not agree to this study - History of eye disease (Addy's syndrome, Horner's syndrome, Sjogren's disease, etc.) or eye surgery - If the patient have a nervous system or metabolic disease (high blood pressure, diabetes, etc.) - Taking medications that may affect the autonomic or central nervous system (anticholinergics, beta blockers/agonists, alpha agonists, antidepressants, antianxiety drugs, anticonvulsants, opioids) - History of substance abuse or mental illness - If the patient are suffering from chronic pain within 2 weeks or if you have taken painkillers before surgery - If the patient are using a pacemaker or have an arrhythmia

Design outcomes

Primary

MeasureTime frame
Occurrence of opioid-induced hyperalgesia

Secondary

MeasureTime frame
Type and total amount of analgesics and anesthetics used;pain score;whether side effects occur

Countries

Korea, Republic of

Contacts

Public ContactJi-Yoon Kim

Hanyang University Seoul Hospital

irisjy00@hanmail.net+82-2-2290-8680

Outcome results

None listed

Source: CRIS (via WHO ICTRP) · Data processed: Feb 4, 2026