None listed
Conditions
Interventions
Procedure/Surgery, Others(antioxidant cosmetic) : This clinical study involves a total of 33 patients exhibiting phenotypes of skin aging such as pigmentation and wrinkles. The treatment will be appli
Sponsors
Yonsei University Yongin Severance Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Healthy male or female subjects between the ages of 30 and 65 who do not meet the exclusion criteria. 2) Individuals who clinically require skin improvement through laser treatment for conditions such as melasma, decreased elasticity, or wrinkles. 3) Subjects who are able to participate in follow-up visits during the clinical trial period. 4) Individuals who have been adequately informed about this clinical trial, can provide written consent at the screening visit, and can comply with the requirements of the clinical trial.
Exclusion criteria
Exclusion criteria: 1) Patients with infectious skin diseases. 2) Patients with a history of other skin diseases at the treatment site besides decreased elasticity, wrinkles, or pigmentation. 3) Patients with keloid disorder or diseases related to collagen and elastic fibers. 4) Patients with psychiatric problems. 5) Individuals at risk of bleeding during treatment due to anticoagulant medication. 6) Individuals allergic to local anesthetics (lidocaine). 7) Pregnant or breastfeeding women, and women who may be pregnant. 8) Individuals with acute or chronic diseases that may affect the study results. 9) Patients who have undergone filler or fat grafting surgery within the last 3 months. 10) Individuals who have used topical steroids for more than 2 weeks to treat skin conditions. 11) Individuals with a history of cosmetic laser treatment, chemical peels, or plastic surgery on the face within 6 months prior to screening. 12) Individuals deemed unsuitable for the clinical trial by the investigator's judgment. 13) Patients who cannot understand the purpose of this clinical trial or cannot comply with the required procedures for treatment and research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Aesthetic Improvement Scale ;9-point Fitzpatrick Wrinkle and Elastosis Scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Half-face modified Melasma Area and Severity Index (hemi-MASI);Modified graffith’s scale;Measuring Skin Pigmentation and Redness;Measurement of skin hydration;Measurement of skin elasticity;Subject skin improvement (satisfaction) survey evaluation;Investigator skin improvement survey evaluation;Assessment of collagen changes through skin tissue biopsy;Assessment of microbiome distribution changes | — |
Countries
Korea, Republic of
Contacts
Public Contactjihee kim
Yonsei University Yongin Severance Hospital
Outcome results
None listed