None listed
Conditions
Interventions
None listed
Sponsors
Gachon University Gil Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Cognitively Normal (CN) - Participants with a Clinical Dementia Rating (CDR) of 0 and without objective evidence of cognitive decline (less than -1.5 standard deviations) based on comprehensive neuropsychological test. 2. Mild Cognitive Impairment (MCI)/mild Alzheimer's dementia (AD) - MCI: Participants with a Clinical Dementia Rating (CDR) of 0.5, but without dementia according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text-revision (DSM-IV-TR) criteria. - AD: Participants with a Clinical Dementia Rating (CDR) of 0.5 or 1 and who meet the DSM-IV-TR criteria for dementia and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable or possible AD.
Exclusion criteria
Exclusion criteria: - Pregnant women (Excluded if even slightly suspected of being pregnant based on surveys or menstrual cycle information) - Women currently breastfeeding - Patients with severely compromised overall health to the extent that conducting tests is difficult - Individuals with seizure such as claustrophobia or other epilepsy - Patients with other major neurological conditions such as traumatic brain injury, Parkinson's disease, Huntington's disease, motor neuron diseases, multiple sclerosis, etc. - Patients who have had a stroke in the cerebrum, brainstem, or cerebellum (Note: Exclusion is only considered if the study director (physician) deems it would significantly affect the study.) - Patients diagnosed with psychiatric disorders such as schizophrenia - Patients with brain tumors, hydrocephalus, encephalitis, or metabolic encephalopathy - Women who are currently pregnant or using intrauterine contraceptive devices - Individuals deemed inappropriate for the study by the clinical researcher - Persons with cardiac pacemakers or metallic implants within the body (Except for titanium and titanium alloy implants, or if a specialist confirms that there are no issues with a 3T MRI scan) - Patients with metallic objects in the head and neck that can cause image distortion during MRI scans
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brain MRI-Based Evaluation of Neurofluid Activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of cerebral blood flow dynamics, Assessment of microvascular elasticity index (MRIR);Plasma biomarkers related to dementia risk factors and blood-brain barrier integrity;Standardized evaluation of memory, attention, language ability, visuospatial functions, and executive function, based on normative data;Physical activity & functional performance and muscle strength assessments | — |
Countries
Korea, Republic of
Contacts
Public ContactYoung Noh
Gachon University Gil Medical Center
Outcome results
None listed