Lifestyle modifications on pediatric metabolic dysfunction-associated steatotic liver disease

Effects of lifestyle modification on liver fat, liver function test, and fecal microbiome in pediatric non-alcoholic fatty liver disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010340

Enrollment

Registered

2025-03-26

Start date

2022-10-07

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Behavioral, Others(lifestyle modification) : Participants engaged in moderate-to-high intensity physical activity for at least 1 hour, 5 times a week, aiming for 10,000 daily steps monitored via weara

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: pediatric patients (aged 10-18) visiting Seoul National University Children's Hospital with hepatic steatosis on liver MRI and at least one cardiometabolic criterion, excluding other causes of steatosis.

Exclusion criteria

Exclusion criteria: Patients were excluded if they had a history of other medication use or alcohol consumption, as well as other causes of liver disease, including HBV, HCV, viral hepatitis, autoimmune hepatitis, metabolic hepatopathy, and muscular disease. Patients with a history of antibiotic use within the past three months, those who had been unable to discontinue probiotics, and those who had been unable to cooperate with examinations were also excluded. Additionally, patients were excluded if their parents or legal guardians had difficulty understanding the study explanation or if they had contraindications for MRI, such as a history of having a pacemaker, implantable defibrillator, deep brain stimulator, ventriculoperitoneal shunt, prosthetic implants, artificial heart valves, metallic implants, cochlear implants, cerebral aneurysm clips, intra-articular pins/screws, insulin or other drug infusion pumps, drug patches, central venous catheters such as chemoports, tattoos or piercings. Furthermore, patients were excluded if the investigator deemed them inappropriate for participation or if they had failed to provide informed consent in prospective studies.

Design outcomes

Primary

Measure	Time frame
Hepatic steatosis improvement;fecal microbiota composition	—

Secondary

Measure	Time frame
factors affecting MRI fat fraction improvement	—

Countries

Korea, Republic of

Contacts

Public ContactJONG WOO HAHN

Seoul National University Hospital

john05@snu.ac.kr+82-31-787-7296

Outcome results