The effect of resting state brain activity within cingulate gyrus in response to escitalopram on the symptom improvement in three generation patients with post-traumatic stress disorder

The effect of resting state brain activity within cingulate gyrus in response to escitalopram on the symptom improvement in three generation patients with post-traumatic stress disorder – prospective, open label, single arm, multicenter, investigator initiated study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010306

Enrollment

Registered

2025-03-14

Start date

2025-02-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : Patients with post-traumatic stress disorder (PTSD) who meet the inclusion and exclusion criteria will begin treatment with escitalopram at 10 mg/day. The dosage will be adjusted within a flexi

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ? Age 15 years or older ? Diagnosed with post-traumatic stress disorder by a board-certified psychiatrist based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria and the Clinician-Administered PTSD Scale ? No history of using antidepressants or antipsychotic medications within four weeks prior to the initial assessment

Exclusion criteria

Exclusion criteria: ? A current or past diagnosis of another psychiatric disorder based on the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria ? Presence of a severe medical condition (e.g., renal failure, liver disease, cancer, hyperthyroidism) ? A current or past history of substance dependence or misuse ? A history of epilepsy, head trauma, or an organic mental disorder

Design outcomes

Primary

Measure	Time frame
Clinician-Administered PTSD Scale	—

Secondary

Measure	Time frame
resting-state functional brain magnetic resonance imaging	—

Countries

Korea, Republic of

Contacts

Public ContactHEE JIN KIM

Chung-Ang University Gwangmyeong Hospital

iamheejin2@caumc.or.kr+82-2-1811-1508

Outcome results