Comparison of the effects of remimazolam and desflurane, general anesthetics, on postoperative acute cognitive function and incidence of altered consciousness (incidence of delirium) in elderly patients undergoing surgery for hip fracture

The effect of desflurane versus remimazolam general anesthesia on postoperative delirium in elderly patients with Hip Fracture: A randomized, controlled, double-blinded clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

CRIS

Registry ID

KCT0010303

Enrollment

Registered

2025-03-14

Start date

2022-09-13

Completion date

Unknown

Last updated

2025-09-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Drug : All patients were administered propofol (1-1.5 mg/kg), fentanyl (0.2-1 mcg/kg), and rocuronium (0.8 mg/kg) to induce anesthesia. After losing consciousness, general anesthesia was maintained d

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 65 years or older who were scheduled to undergo hip surgery under general anesthesia at Ansan Korea University Hospital after hip fracture were eligible for the study.

Exclusion criteria

Exclusion criteria: We excluded patients who (i) refused to participate in the study, (ii) refused blood tests, (iii) underwent surgery under regional anesthesia, (iv) were intolerant to the drugs used in this study, (v) were diagnosed with severe cognitive impairment (MMSE-K score = 20), (vi) had Alzheimer's disease, schizophrenia, or severe depression, and (vii) had a history of stroke or delirium within 6 months.

Design outcomes

Primary

Measure	Time frame
The primary endpoint was the difference in the incidence of delirium up to 5 days postoperatively between remimazolam-based and desflurane-based general anesthesia	—

Secondary

Measure	Time frame
Secondary endpoints included ICU admission during the first 5 days after surgery and major complications within 5 days.;Other secondary endpoints include blood sample collection and analysis of delirium-related factors. Blood tests will measure interleukin-6 (IL-6), a delirium-related factor in patients.;Measuring glial fibrillary acidic protein (GFAP), a delirium-related factor in patients, through blood tests;Measuring NSE(Neuron-Specific Enolase), a delirium-related factor in patients, through blood tests	—

Measure

Time frame

Secondary endpoints included ICU admission during the first 5 days after surgery and major complications within 5 days.;Other secondary endpoints include blood sample collection and analysis of delirium-related factors. Blood tests will measure interleukin-6 (IL-6), a delirium-related factor in patients.;Measuring glial fibrillary acidic protein (GFAP), a delirium-related factor in patients, through blood tests;Measuring NSE(Neuron-Specific Enolase), a delirium-related factor in patients, through blood tests

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Countries

Korea, Republic of

Contacts

Public ContactSU MI LEE

Korea University Ansan Hospital

beluga1004@naver.com+82-31-412-5297

Outcome results